Ori et al. 2015 (PRJNA277771)
General Details
Title | Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats |
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Organism | |
Number of Samples | 22 |
Release Date | 2015/03/09 00:00 |
Sequencing Types | |
Protocol Details |
Study Links
GWIPS-viz | Trips-Viz |
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Visit GWIPS-viz | Visit Trips-Viz |
Repository Details
SRA | SRP056012 |
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ENA | SRP056012 |
GEO | |
BioProject | PRJNA277771 |
Publication
Title | |
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Authors | Ori A,Toyama BH,Harris MS,Bock T,Iskar M,Bork P,Ingolia NT,Hetzer MW,Beck M |
Journal | Cell systems |
Publication Date | 2015 Sep 23 |
Abstract | Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old animals. The majority are a consequence of altered translation output, that is, the combined effect of changes in transcript abundance and translation efficiency. In addition, we identify 130 proteins whose overall abundance remains unchanged but whose sub-cellular localization, phosphorylation state, or splice-form varies. While some protein-level differences appear to be a generic property of the rats' chronological age, the majority are specific to one organ. These may be a consequence of the organ's physiology or the chronological age of the cells within the tissue. Taken together, our study provides an initial view of the proteome at the molecular, sub-cellular, and organ level in young and old rats. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. |
PMC | PMC4802414 |
PMID | 27135913 |
DOI |
Run Accession | Study Accession | Scientific Name | Cell Line | Library Type | Treatment | GWIPS-viz | Trips-Viz | Reads | BAM | BigWig (F) | BigWig (R) | ||
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SRR1873526 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873527 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873528 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873529 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873530 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873531 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873532 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873533 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873534 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873535 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873536 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873537 | PRJNA277771 | Rattus norvegicus | Ribo-Seq | ||||||||||
SRR1873538 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
SRR1873539 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
SRR1873540 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
SRR1873541 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
SRR1873542 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
SRR1873543 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
SRR1873544 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
SRR1873545 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
SRR1873546 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
SRR1873547 | PRJNA277771 | Rattus norvegicus | RNA-Seq | ||||||||||
Run Accession | Study Accession | Scientific Name | Cell Line | Library Type | Treatment | GWIPS-viz | Trips-Viz | Reads | BAM | BigWig (F) | BigWig (R) |
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