Datasets

Title	Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes
Organism
Number of Samples	12
Release Date	2024/06/13 00:00
Sequencing Types
Protocol Details

Title
Authors	Liu Y,Hoskins I,Geng M,Zhao Q,Chacko J,Qi K,Persyn L,Wang J,Zheng D,Zhong Y,Rao S,Park D,Cenik ES,Agarwal V,Ozadam H,Cenik C
Journal	bioRxiv : the preprint server for biology
Publication Date	2024 Aug 11
Abstract	Characterization of shared patterns of RNA expression between genes across conditions has led to the discovery of regulatory networks and novel biological functions. However, it is unclear if such coordination extends to translation, a critical step in gene expression. Here, we uniformly analyzed 3,819 ribosome profiling datasets from 117 human and 94 mouse tissues and cell lines. We introduce the concept of Translation Efficiency Covariation (TEC), identifying coordinated translation patterns across cell types. We nominate potential mechanisms driving shared patterns of translation regulation. TEC is conserved across human and mouse cells and helps uncover gene functions. Moreover, our observations indicate that proteins that physically interact are highly enriched for positive covariation at both translational and transcriptional levels. Our findings establish translational covariation as a conserved organizing principle of mammalian transcriptomes.
PMC	PMC11326257
PMID	39149359
DOI

Liu et al. 2024 (PRJNA1123575)