Datasets

Title	Genome-wide translational changes induced by the prion [PSI+]
Organism
Number of Samples	8
Release Date	2012/10/15 00:00
Sequencing Types
Protocol Details

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Title
Authors	Baudin-Baillieu A,Legendre R,Kuchly C,Hatin I,Demais S,Mestdagh C,Gautheret D,Namy O
Journal	Cell reports
Publication Date	2014 Jul 24
Abstract	Prions are infectious proteins that can adopt a structural conformation that is then propagated among other molecules of the same protein. [PSI(+)] is an aggregated conformation of the translational release factor eRF3. [PSI(+)] modifies cellular fitness, inducing various phenotypes depending on genetic background. However, the genes displaying [PSI(+)]-controlled expression remain unknown. We used ribosome profiling in isogenic [PSI(+)] and [psi(-)] strains to identify the changes induced by [PSI(+)]. We found 100 genes with stop codon readthrough events and showed that many stress-response genes were repressed in the presence of [PSI(+)]. Surprisingly, [PSI(+)] was also found to affect reading frame selection independently of its effect on translation termination efficiency. These results indicate that [PSI(+)] has a broader impact than initially anticipated, providing explanations for the phenotypic differences between [psi(-)] and [PSI(+)] strains. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
PMC
PMID	25043188
DOI

Baudin-Baillieu et al. 2015 (PRJNA177820)