Ori et al. 2015 (PRJNA277771)

General Details

Title Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
Organism
Number of Samples 22
Release Date 2015/03/09 00:00
Sequencing Types
Protocol Details

Study Links

Repository Details

SRA SRP056012
ENA SRP056012
GEO GSE66715
BioProject PRJNA277771

Publication

Title
Authors Ori A,Toyama BH,Harris MS,Bock T,Iskar M,Bork P,Ingolia NT,Hetzer MW,Beck M
Journal Cell systems
Publication Date 2015 Sep 23
Abstract Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old animals. The majority are a consequence of altered translation output, that is, the combined effect of changes in transcript abundance and translation efficiency. In addition, we identify 130 proteins whose overall abundance remains unchanged but whose sub-cellular localization, phosphorylation state, or splice-form varies. While some protein-level differences appear to be a generic property of the rats' chronological age, the majority are specific to one organ. These may be a consequence of the organ's physiology or the chronological age of the cells within the tissue. Taken together, our study provides an initial view of the proteome at the molecular, sub-cellular, and organ level in young and old rats. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
PMC PMC4802414
PMID 27135913
DOI
Run Accession Study Accession Scientific Name Cell Line Library Type Treatment GWIPS-viz Trips-Viz Reads BAM BigWig (F) BigWig (R)
SRR1873526 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873527 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873528 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873529 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873530 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873531 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873532 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873533 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873534 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873535 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873536 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873537 PRJNA277771 Rattus norvegicus Ribo-Seq
SRR1873538 PRJNA277771 Rattus norvegicus RNA-Seq
SRR1873539 PRJNA277771 Rattus norvegicus RNA-Seq
SRR1873540 PRJNA277771 Rattus norvegicus RNA-Seq
SRR1873541 PRJNA277771 Rattus norvegicus RNA-Seq
SRR1873542 PRJNA277771 Rattus norvegicus RNA-Seq
SRR1873543 PRJNA277771 Rattus norvegicus RNA-Seq
SRR1873544 PRJNA277771 Rattus norvegicus RNA-Seq
SRR1873545 PRJNA277771 Rattus norvegicus RNA-Seq
SRR1873546 PRJNA277771 Rattus norvegicus RNA-Seq
SRR1873547 PRJNA277771 Rattus norvegicus RNA-Seq
Run Accession Study Accession Scientific Name Cell Line Library Type Treatment GWIPS-viz Trips-Viz Reads BAM BigWig (F) BigWig (R)

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