Cho et al. 2015 (PRJNA292861)

General Details

Title Genome-wide profilings of transcriptome and translatome in mouse hippocampi after contextual fear conditioning
Organism
Number of Samples 18
Release Date 2015/08/14 00:00
Sequencing Types
Protocol Details

Study Links

Repository Details

SRA SRP062407
ENA SRP062407
GEO GSE72064
BioProject PRJNA292861

Publication

Title
Authors Cho J, Yu NK, Choi JH, Sim SE, Kang SJ, Kwak C, Lee SW, Kim JI, Choi DI, Kim VN, Kaang BK
Journal Science (New York, N.Y.)
Publication Date 2015 Oct 2
Abstract Memory stabilization after learning requires translational and transcriptional regulations in the brain, yet the temporal molecular changes that occur after learning have not been explored at the genomic scale. We used ribosome profiling and RNA sequencing to quantify the translational status and transcript levels in the mouse hippocampus after contextual fear conditioning. We revealed three types of repressive regulations: translational suppression of ribosomal protein-coding genes in the hippocampus, learning-induced early translational repression of specific genes, and late persistent suppression of a subset of genes via inhibition of estrogen receptor 1 (ESR1/ERα) signaling. In behavioral analyses, overexpressing Nrsn1, one of the newly identified genes undergoing rapid translational repression, or activating ESR1 in the hippocampus impaired memory formation. Collectively, this study unveils the yet-unappreciated importance of gene repression mechanisms for memory formation. Copyright © 2015, American Association for the Advancement of Science.
PMC
PMID 26430118
DOI
Run Accession Study Accession Scientific Name Cell Line Library Type Treatment GWIPS-viz Trips-Viz Reads BAM BigWig (F) BigWig (R)
SRR2163083 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163084 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163085 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163086 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163087 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163093 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163094 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163095 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163096 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163097 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163103 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163104 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163105 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163106 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163107 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163113 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2163114 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
SRR2733385 PRJNA292861 Mus musculus 0.0 Ribo-Seq 0.0
Run Accession Study Accession Scientific Name Cell Line Library Type Treatment GWIPS-viz Trips-Viz Reads BAM BigWig (F) BigWig (R)

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