Laguesse et al. 2015 (PRJNA301154)

Title	A dynamic unfolded protein response contributes to the control of cortical neurogenesis
Organism
Number of Samples	4
Release Date	2015/11/04 00:00
Sequencing Types
Protocol Details

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Title
Authors	Laguesse S,Creppe C,Nedialkova DD,Prévot PP,Borgs L,Huysseune S,Franco B,Duysens G,Krusy N,Lee G,Thelen N,Thiry M,Close P,Chariot A,Malgrange B,Leidel SA,Godin JD,Nguyen L
Journal	Developmental cell
Publication Date	2015 Dec 7
Abstract	The cerebral cortex contains layers of neurons sequentially generated by distinct lineage-related progenitors. At the onset of corticogenesis, the first-born progenitors are apical progenitors (APs), whose asymmetric division gives birth directly to neurons. Later, they switch to indirect neurogenesis by generating intermediate progenitors (IPs), which give rise to projection neurons of all cortical layers. While a direct lineage relationship between APs and IPs has been established, the molecular mechanism that controls their transition remains elusive. Here we show that interfering with codon translation speed triggers ER stress and the unfolded protein response (UPR), further impairing the generation of IPs and leading to microcephaly. Moreover, we demonstrate that a progressive downregulation of UPR in cortical progenitors acts as a physiological signal to amplify IPs and promotes indirect neurogenesis. Thus, our findings reveal a contribution of UPR to cell fate acquisition during mammalian brain development. Copyright © 2015 Elsevier Inc. All rights reserved.
PMC
PMID	26651292
DOI

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