Cheng et al. 2018 (PRJNA428526)

General Details

Title Pervasive, coordinated protein level changes driven by transcript isoform switching during meiosis
Organism
Number of Samples 46
Release Date 2018/01/04 00:00
Sequencing Types
Protocol Details

Study Links

Repository Details

SRA SRP128065
ENA SRP128065
GEO GSE108778
BioProject PRJNA428526

Publication

Title
Authors Cheng Z, Otto GM, Powers EN, Keskin A, Mertins P, Carr SA, Jovanovic M, Brar GA
Journal Cell
Publication Date 2018 Feb 22
Abstract To better understand the gene regulatory mechanisms that program developmental processes, we carried out simultaneous genome-wide measurements of mRNA, translation, and protein through meiotic differentiation in budding yeast. Surprisingly, we observed that the levels of several hundred mRNAs are anti-correlated with their corresponding protein products. We show that rather than arising from canonical forms of gene regulatory control, the regulation of at least 380 such cases, or over 8% of all measured genes, involves temporally regulated switching between production of a canonical, translatable transcript and a 5' extended isoform that is not efficiently translated into protein. By this pervasive mechanism for the modulation of protein levels through a natural developmental program, a single transcription factor can coordinately activate and repress protein synthesis for distinct sets of genes. The distinction is not based on whether or not an mRNA is induced but rather on the type of transcript produced. Copyright © 2018 Elsevier Inc. All rights reserved.
PMC PMC5826577
PMID 29474919
DOI
Run Accession Study Accession Scientific Name Cell Line Library Type Treatment GWIPS-viz Trips-Viz Reads BAM BigWig (F) BigWig (R)
SRR6441591 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441592 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441593 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441594 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441595 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441596 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441597 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441598 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441599 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441600 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441621 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441622 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441623 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441624 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441625 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441626 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441627 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441628 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441645 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441646 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441647 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441648 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441649 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441650 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441651 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441652 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441653 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441654 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441675 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441676 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441677 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441678 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441679 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441680 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441681 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441682 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441699 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441700 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441701 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441702 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441703 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441704 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441705 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441706 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441707 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
SRR6441708 PRJNA428526 Saccharomyces cerevisiae SK1 Ribo-Seq 0.0
Run Accession Study Accession Scientific Name Cell Line Library Type Treatment GWIPS-viz Trips-Viz Reads BAM BigWig (F) BigWig (R)

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