Nakayama et al. 2019 (PRJNA490651)

Title	Genome-wide transcriptome analysis of brain region (ventral part of telenchephalon, hypothalamus and pituitary) in medaka [Ribo-Seq]
Organism
Number of Samples	2
Release Date	2018/09/13 00:00
Sequencing Types
Protocol Details

GWIPS-viz	Trips-Viz

Title
Authors	Nakayama T,Shimmura T,Shinomiya A,Okimura K,Takehana Y,Furukawa Y,Shimo T,Senga T,Nakatsukasa M,Nishimura T,Tanaka M,Okubo K,Kamei Y,Naruse K,Yoshimura T
Journal	Nature ecology & evolution
Publication Date	2019 May
Abstract	To cope with seasonal environmental changes, animals adapt their physiology and behaviour in response to photoperiod. However, the molecular mechanisms underlying these adaptive changes are not completely understood. Here, using genome-wide expression analysis, we show that an uncharacterized long noncoding RNA (lncRNA), LDAIR, is strongly regulated by photoperiod in Japanese medaka fish (Oryzias latipes). Numerous transcripts and signalling pathways are activated during the transition from short- to long-day conditions; however, LDAIR is one of the first genes to be induced and its expression shows a robust daily rhythm under long-day conditions. Transcriptome analysis of LDAIR knockout fish reveals that the LDAIR locus regulates a gene neighbourhood, including corticotropin releasing hormone receptor 2, which is involved in the stress response. Behavioural analysis of LDAIR knockout fish demonstrates that LDAIR affects self-protective behaviours under long-day conditions. Therefore, we propose that photoperiodic regulation of corticotropin releasing hormone receptor 2 by LDAIR modulates adaptive behaviours to seasonal environmental changes.
PMC
PMID	30962562
DOI

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