Hendriks et al. 2014 (PRJNA230377)

General Details

Title Developmental Timecourses total-RNA sequencing [Ribosome repleted total RNA]
Organism
Number of Samples 38
Release Date 2013/12/02 00:00
Sequencing Types
Protocol Details

Study Links

Repository Details

SRA SRP033412
ENA SRP033412
GEO
BioProject PRJNA230377

Publication

Title
Authors Hendriks GJ,Gaidatzis D,Aeschimann F,Großhans H
Journal Molecular cell
Publication Date 2014 Feb 6
Abstract Oscillations are a key to achieving dynamic behavior and thus occur in biological systems as diverse as the beating heart, defecating worms, and nascent somites. Here we report pervasive, large-amplitude, and phase-locked oscillations of gene expression in developing C. elegans larvae, caused by periodic transcription. Nearly one fifth of detectably expressed transcripts oscillate with an 8 hr period, and hundreds change >10-fold. Oscillations are important for molting but occur in all phases, implying additional functions. Ribosome profiling reveals that periodic mRNA accumulation causes rhythmic translation, potentially facilitating transient protein accumulation as well as coordinated production of stable, complex structures such as the cuticle. Finally, large-amplitude oscillations in RNA sampled from whole worms indicate robust synchronization of gene expression programs across cells and tissues, suggesting that these oscillations will be a powerful new model to study coordinated gene expression in an animal. Copyright © 2014 Elsevier Inc. All rights reserved.
PMC
PMID 24440504
DOI
Run Accession Study Accession Scientific Name Cell Line Library Type Treatment GWIPS-viz Trips-Viz Reads BAM BigWig (F) BigWig (R)
SRR1041221 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041222 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041223 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041224 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041225 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041226 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041227 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041228 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041229 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041230 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041231 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041232 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041233 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041234 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041235 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041236 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041237 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041238 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041239 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041240 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041241 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041242 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041243 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041244 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041245 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041246 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041247 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041248 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041249 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041250 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041251 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041252 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041253 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041254 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041255 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041256 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041257 PRJNA230377 Caenorhabditis elegans RNA-Seq
SRR1041258 PRJNA230377 Caenorhabditis elegans RNA-Seq
Run Accession Study Accession Scientific Name Cell Line Library Type Treatment GWIPS-viz Trips-Viz Reads BAM BigWig (F) BigWig (R)

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